The outcome of the Dutch-Belgian Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON) trial has been much anticipated. "Randomized Comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study". Found inside – Page 610In the second place , it is with a larger dose of certain other organisms which are hoped that the establishment of the ... week one of those prolonged trials of automobiles following results of Mr. Gilruth's invertigations are worth to which this club ... Found inside – Page 5108... of the debate format journal club to teach critical ( comment ) Buring JE , et al . ... A simple measure in defining optimal strata in clinical trials . received in both groups. 2530 n engl j med 381;26 nejm.orgDecember 26, 2019 The new england journal of medicine V itamin D may improve outcomes in critically ill patients. Second, although the trial was large for a study of a rare disease, some estimates had wide confidence intervals, and potential differences in outcomes with respect to plasma exchange or the reduced-dose glucocorticoid regimen remain possible, as discussed above. Its use in acute SCI has been the subject of controversy for over 30 years. Jacoby graciously accepted to participate in this event, and I'm joined by Drs. Typically, when estimated glomerular filtration rate is . Found inside – Page 455After sacrificing the treated and untreated rats , 500 mg amount of the compound in 5 or 10 doses the livers were removed in normal saline . ... had dead larvae . three dose schedule ( 100 mg / kg * 5 , 50 mg / kg x 5 , In simultaneous trial mebendazole showed paraland 25 ... was Multiple dose treatment of the total dose of 500 mg found covered with club shaped microtriches interkg of the metabolite ( 100 ... Because cardiologists and intensivists do not see the same patients and/or do not have the same background, this book represents a joint effort from internationally known cardiologists and intensivists to set up a single reference resource, ... Held on 2nd and 4th Tuesdays at 12:30pm EST (usually 9:30am Pacific, 5:30pm GMT, 11:00pm Indian Standard) Authors present for 15 minutes followed by 15 minutes answers to written Q&A. Packer M, Poole-Wilson PA, Armstrong PW . Background: In the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial, patients with atrial fibrillation and ≥2 dose-adjustment criteria (age ≥80 years, weight ≤60 kg, or creatinine ≥1.5 mg/dl [133 μmol/l]) were randomized to receive apixaban 2.5 mg twice daily or warfarin. Complete Journal Club Article Mercedes Ortiz, Alfonso Martín, Fernando Arribas, Blanca Coll-Vinent, Carmen del Arco, Rafael Peinado, Jesús Almendral. Devices: 1% CRT, 4% ICD. In the management of airway disease, escalation of treatment often happens more readily than reduction. Among patients with acute decompensated HF, how do continuous vs. intermittent and low- vs. Found insideIs the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book. Complete Journal Club Article Tsutsumi S. et al.. "Effects of the Second National Acute Spinal Cord Injury Study of high-dose methylprednisolone therapy on acute cervical spinal cord … The secondary outcome of dose switching occurred in 7.1% in the aspirin 81 mg group compared with 41.6% of the aspirin 325 mg group. We hope that facilitating discussion of this research will help physiotherapists to implement the results into their clinical practice. The first large, controlled trial of occipital nerve stimulation for medically intractable chronic cluster headache shows potential as a long-term preventive treatment. The Diuretic Optimization Strategies Evaluation (DOSE) study, published in the New England Journal of Medicine, randomized 308 ADHF patients to a bolus every 12 hours or a continuous infusion of furosemide at either a high or low dose. Journal Club | Volume 99, ISSUE 6, P1252-1254, June 01, 2021. Steroid resistance- Absence of remission despite therapy with daily prednisolone at a dose of 2 mg/kg per day for 4 weeks. The much-anticipated HALT-IT trial was finally published in the Lancet this week and the results just might surprise you…. For this round of NephJC, we have somewhat of a rarity in the nephrology literature - a randomized clinical trial with a positive result! Dose discordance: reported for 10 drugs, percentage of instances in which the equation would recommend a different dose than the CG estimate. Found insideDrug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. JAMA 2020. May - 2019. Patients in APROCCHSS were sicker than those in the ADRENAL trial. Found insideThe Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. The second National Acute Spinal Cord Injury Study (NASCIS-2) demonstrated a small benefit of methylprednisolone,1 though this conclusion was derived from a post hoc subgroup … This phase 2 single centre trial adds the next step to an important question - does the early commencement of low-dose norepinephrine in patients with septic shock resuscitation result in improved outcomes? Placebo Median duration of trial drug was 19.5 months In contrast to the trials of purified EPA, this trial administered an omega-3 CA formulation composed of both EPA and DHA. Interpretation: Among patients with ASCVD, aspirin 325 mg was not superior compared with 81 mg. Aspirin 325 mg was not associated with a reduction in all-cause death, MI, or stroke compared with 81 mg daily. Chang AK et al. IACH Journal Club - Video Library Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk Dr. Shambavi Richard, Dr. Salomon Mainer July 20, 2021 CPX-351 versus 7+3 cytarabine and daunorubicin chemotherapy in older adults with newly diagnosed high-risk or secondary acute myeloid leukaemia Prof. Evidence has accumulated to support the efficacy of CI therapy for rehabilitating hemiparetic arm use in individuals with chronic stroke. This book addresses the related topics. In line with this, clinical trials usually focus on the up-titration or addition of medications and few trials are available to also guide reduction in treatment. , et al, on behalf of the ATLAS Study Group . Found inside – Page 710Their statement regarding biomedical journal manuscripts is broad and ... for dose-finding studies and safety and activity trials remains highly variable. The discussion includes all residents and is led by senior residents or our research director, Dr. Michael Plewa. In half the patients, vitamin C … For more information, check out the CardioNerds Journal Club Page. Journal Club – Nov 2019 Drs. Plavix) [5][6]. Strengths: Large, pragmatic, randomized controlled trial. Objectives: This study conducted a prospective, single-arm, multicenter trial to evaluate the safety and efficacy of ultrasound-facilitated, catheter-directed, low-dose fibrinolysis, using the EkoSonic Endovascular System (EKOS, Bothell, Washington). CardioNerds Journal Club is a monthly forum for Cardionerds to discuss and breakdown recent publications on twitter and are produced with a corresponding infographic and detailed blog post. Found inside – Page 127A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency ... APC Journal Club, 123(3), A12–A13. Found inside – Page 74CRASH-2 Trial Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients ... The dose selected in this study, of 1 g over 10 minutes as the loading dose followed by a second 1 g dose over 8 hours, ... These journal club posts are designed to provide you with a deeper dive into the paper, addressing what the … March 7, 2021. Rapid blood-pressure lowering in … The aim of this pragmatic, double-blind, randomised, placebo-controlled trial is to determine whether low-dose amitriptyline (an antidepressant) is more effective … The trial included 15,076 patients and had a … Found inside – Page 76... treatment in severe sepsis: a “journal club” review of the global ENHANCE trial. ... A controlled clinical trial of high-dose methylprednisolone in the ... Design, Setting, and Participants Multicenter randomized trial with a 2 × 2 factorial design performed in 10 academic centers in Iran comparing intermediate-dose vs standard-dose prophylactic anticoagulation (first hypothesis) and statin therapy vs matching placebo (second hypothesis; not reported in this article) among adult patients admitted to the ICU with COVID-19. The mean age of this cohort was 66 years, with 36% of patients being female, and half having at least one comorbidity. Found inside – Page 73... were studies of clinical efficacy trials from a wide range of journals, ... (MPG Journal Club, March 2007) As you can see, the article summary genre ... Cefiderocol was non-inferior to high-dose, extended-infusion meropenem in terms of all-cause mortality on day 14 in patients with Gram-negative nosocomial pneumonia, with similar tolerability. The trial included 8,509 patients with moderate to severe COPD randomized in similar numbers to treatment with twice-daily inhaled, fixed-dose … The results suggest that cefiderocol is a potential option for the treatment of patients with nosocomial pneumonia, including those caused by multidrug-resistant Gram-negative bacteria. The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) trial randomized 12,562 patients with UA/NSTEMI to either dual antiplatelet therapy with aspirin plus plavix or to aspirin alone immediately upon presentation. But the trial falls short of proving that vitamin C does not improve sepsis outcomes: Patients could be enrolled up to 24 hours after developing septic shock. Article: Roberts I et al. Nona Jiang and Golsa Joodi, who are also my co-residents. Found insideParenting Matters identifies parenting knowledge, attitudes, and practices associated with positive developmental outcomes in children ages 0-8; universal/preventive and targeted strategies used in a variety of settings that have been ... Found inside – Page 163( 1998 ) , ' Effectiveness of high - dose riboflavin in migraine prophylaxis ... other agents or for prophylaxis ' , ACP Journal Club , January / February . Found inside – Page 85The Xerophthalmia Club will promote measures which could help to prevent and cure mainutritional blindness , particularly ... Swaminathan MC , Susheela Thimmayomma BVS : Field prophylactic trial with a single annoal oral massive dose of ... Found inside – Page 257Randomized trials stopped early for benefit. Presented at Journal Club, Infectious Diseases Division, Duke University School of medicine, Durham, ... Even before the second dose, BNT162b2 was highly efficacious, with a vaccine efficacy of 92.6%, a finding similar to the first-dose efficacy of 92.1% … For example, on average patients in APROCCHSS were on ~70 mcg/min norepinephrine, whereas patients in the ADRENAL trial were on ~30 mcg/min. Found inside – Page 4381 1 The articles reviewed in the Journal Club department focus on ... 3 ( 4 ) In a long - term , open - label extension trial , adverse events possibly related to Renagel® Capsules and which were not dose - related , included nausea ( 7 % ) ... Of controversy for over 30 years in sepsis stroke prophylaxis dose approved for (. Intracranial aneurysm after subarachnoid hemorrhage ( SAH ) is associated with unfavorable outcome assessed by radionuclide-determined EF to. 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