Place the tip of the tube on the skin and squeeze tube firmly to apply solution directly to the skin. Objectives. Cautions. Moxiclear is broad spectrum endectocide spot-on for very large cats (>4 ≤ 8 kg) containing imidacloprid and moxidectin. Resources. Please refer to section 4.5. The efficacy and safety of a combination formulation of 10% imidacloprid + 1.0% moxidectin spot-on (Advocate® for Cats, Bayer Animal Health GmbH, Leverkusen, Germany) was tested in 40 African pygmy hedgehogs (Atelerix albiventris) naturally infested with Caparinia tripilis. Imidacloprid and moxidectin is not recommended for animals that are nursing, pregnant, debilitated, or geriatric. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. Advantage Multi ® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Two studies were conducted to evaluate and compare the efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 flea strain infesting cats. For cats, the recommended minimum dose is 4.5 mg/lb. Excipients: Benzyl alcohol . This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Each milliliter of constituted, sustained-release suspension contains 3.4 mg of moxidectin The formulation Advantage Multi for dogs 2.5% (25mg/mL) includes 25% Imidacloprid. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. Butylhydroxytoluene 1 mg/ml (E 321; as antioxidant). cats. Advocate for Cats Over 4 kgActive ingredientsImidacloprid 100g/L and moxidectin 10g/L solution for topical application onto cats. To compare the efficacy of two spot‐on treatments of moxidectin/imidacloprid, two weeks apart to a single oral dose of fluralaner against Lynxacarus radovskyi and evaluate time to re‐infestation. The active ingredients in Advantage Multi for Cats are Imidacloprid and Moxidectin . The results of this study demonstrate that imidacloprid+moxidectin topical solution can be used safely in cats heavily infected with adult D. immitis. Ferrets: Imidacloprid plus moxidectin for ferrets and is dosed according to weight. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. IMIDACLOPRID: 100 mg/mL (= 10.0%) MOXIDECTIN: 25 mg/mL for dogs (= 2.5%) 10 mg/mL for cats (= 1.0%) CHEMICAL CLASS of the active ingredient(s): Imidacloprid: NEONICOTINOID; Moxidectin: MACROCYCLIC LACTONE The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Overview of Advantage Multi™ for Canines and Felines Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Dosage schedule for ferrets: one pipette of Advocate spot-on solution for small cats … Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. Active Ingredient Do not exceed the recommended dose. Advantage Multi for Cats is not for human use, and should always be kept out of the reach of children. Includes both imidacloprid (100g/L) and moxidectin (10g/L) : ... Moxiclear’s combination of Moxidectin and Imidacloprid has been shown to be safe in kittens when given from 9 weeks of age. Available in packs of 3 or 6 . The recommended minimum dose is 10 milligrams per kilogram imidacloprid and 1 milligram per kilogram moxidectin once a month by topical administration. What is Advocate and what is it used for? When used as directed on the label, imidacloprid with moxidectin is safe in most cats and ferrets. Administer the entire contents of the Advantage Multi ® for Cats tube that correctly corresponds with the body weight of the cat. Common Precautions. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). Available in packs containing 3 and 6 pipettes of 0.4 and 0.8mL dose sizes.ActionImidacloprid exerts its effect by binding to post synaptic nicotinic receptors, blocking Parasitol Res 112 Suppl 1, 57-66 PubMed. Moxidectin also affects the nervous system in parasites and protects against heartworms. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Cats: Imidacloprid plus moxidectin comes in 3 different sizes for cats and is dosed according to weight. Lynxacarus radovskyi has been observed in cats in Malaysia; previously treatment with fipronil and moxidectin/imidacloprid spot‐on has been described.. Do not use on canaries. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate® spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). A single treatment with this formulation also provided 88.4-100% control of adult C. felis for 35 days. Each tube contains: IMIDACLOPRID & MOXIDECTIN. Advantage Multi® for Cats (10 % imidacloprid + 1 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. This product may also be used monthly for prevention of heartworm infection and to treat flea infestations in ferrets. Weight of cat [kg] Pipette size to be used Volume [ml] Imidacloprid [mg/kg bw] Moxidectin [mg/kg bw] For dogs, the corresponding “Endectrid for dogs” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Background. Advantage Multi for cats 1% (10mg/mL) includes 10% Imidacloprid. There were no statistically significant differences in the comparison of adult D. immitis recovered at necropsy (ANOVA overall group effect P-value of 0.5356). Each unit dose (pipette) contains: Unit dose Imidacloprid Moxidectin Advocate for small cats (≤ 4 kg) and ferrets 0.4 ml 40 mg 4 mg Advocate for large cats (> 4–8 kg) 0.8 ml 80 mg 8 mg . Advocate for cats contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin. Directions for use: Use the top of the cap to break seal of tube. The study was performed as a multicentre, non-random … Legal Category POM-V. Do not let animal lick treated area; keep other pets and children away from treated animals until the area has dried (about 30 (10.0 mg/kg) imidacloprid and 0.45 mg/lb. Please refer to section 4.5. Each group comprised 8 animals and the treatment dose was 10 mg/kg bodyweight (bw) imidacloprid and 1 mg/kg bw moxidectin in each study. The treatment schedule should be based on the local epidemiological situation. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. (1.0 mg/kg) moxidectin once a month by topical administration. The treatment schedule for all species should be based on individual veterinary diagnoses and on the local epidemiological situation. 4.4 Special warnings for each target species. The formulation containing 10% imidacloprid and 1% moxidectin was 100% efficacious against the development of adult D. immitis infections when cats were treated 30 days after inoculation with third-stage larvae. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. Do not use on canaries. Advantage Multi for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). For Kittens, Small Cats & Ferrets up to 4 kg . imidacloprid / moxidectin) An overview of Advocate and why it is authorised in the EU . Hellmann K, Petry G, Capari B, Cvejic D, Krämer F (2013) Treatment of naturally Notoedres cati-infested cats with a combination of imidacloprid 10 % / moxidectin 1 % spot-on (Advocate® / Advantage® Multi, Bayer). For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Moxiclear spot-on solution for large cats. For dogs, the corresponding “Endectrid for dog” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. It is frequently used in combination with other medications to treat a variety of parasites. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. 4.4 Special warnings for each target species. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Imidacloprid plus moxidectin (Advantage® Multi for Cats, Bayer) was used as a positive control in both studies at the label dosage. The recommended minimum doses for cats are 10 mg/kg body weight imidacloprid and 1.0 mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Advocate for cats. METHODS: Cats were experimentally inoculated with 300-800 third-stage larvae (L3). Part hair between the shoulder blades until skin is visible. For Cats Over 4kg. Imidacloprid attacks the nervous system in insects, which causes impairment and subsequently death. Advocate is a medicine used on cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections (caused by several different types of parasites): It will also treat and control whipworms in dogs and ear mites in cats. The recommended minimum doses for cats are 10mg/kg body weight imidacloprid and 1.0mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Endectrid for Cats. Order of a licensed veterinarian most cats and is dosed according to weight, pregnant,,... 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